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目的评价TCT和HPV-DNA检测在CINⅠ患者随访中的应用价值。方法选取2010年1月—2012年6月于我院就诊经阴道镜活检病理诊断为CINⅠ的患者215例(排除既往CIN病史),年龄20~66岁,平均30.5岁。所有患者来访1~5次,平均2.5次,随访间隔时间3~9个月,平均5.5个月,随访时间9~18个月,平均12.8个月。复查内容包括TCT、高危型HPV-DNA及阴道镜检查。以阴道镜下活检检查为最终诊断。结果 TCT单项诊断的灵敏度为75.54%,HPV-DNA检测单项诊断的灵敏度为80.23%,二者联合诊断的灵敏度为96.78%,比较差异有统计学意义。结论液基细胞学检查联合人类乳头瘤病毒筛查能提高随访结果的敏感率和准确性,有利于准确评估病情,为后续治疗提供依据。
Objective To evaluate the value of TCT and HPV-DNA in the follow-up of CINⅠ patients. Methods From January 2010 to June 2012, 215 patients with CINⅠ who underwent colposcopic biopsy in our hospital (excluding the history of previous CIN) were selected, aged from 20 to 66 years (average 30.5 years). All patients visited 1 to 5 times, with an average of 2.5 times. The follow-up interval was 3 to 9 months with an average of 5.5 months. The follow-up time ranged from 9 to 18 months (average 12.8 months). Review include TCT, high-risk HPV-DNA and colposcopy. Colposcopy biopsy for the final diagnosis. Results The sensitivity of single diagnosis of TCT was 75.54%. The sensitivity of single diagnosis of HPV-DNA test was 80.23%. The sensitivity of combined diagnosis was 96.78%. The difference was statistically significant. Conclusion Liquid-based cytology combined with human papillomavirus (HPV) screening can improve the sensitivity and accuracy of follow-up results, which is helpful to accurately assess the disease and provide the basis for follow-up treatment.