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慢性肾功能衰竭(CRF)患者极易继发感染,且感染发生后常无明显的全身反应。原因是病人的免疫功能低下。免疫功能低下的机制是:①T淋巴细胞中,具有辅助和诱导作用的C_4亚群较正常人显著降低,外周血T淋巴细胞总数CD_3亚群显著减少,而具有抑制和细胞毒功能的CD_3亚群较正常显著增高。上述改变与血清肌酐(Scr)值显著相关,是血清尿毒素中的免疫抑制因子作用的结果。此外,中、重度营养不良亦可引起这些变化。②尿毒症时粒细胞的葡萄糖代谢障碍,运动和吞噬反应能力受损。⑧营养缺乏也是重要因素。中、重度的营养不良亦可造成
Patients with chronic renal failure (CRF) are extremely susceptible to secondary infection and often have no apparent systemic reaction after infection. The reason is the patient’s immune function is low. The mechanisms of immune dysfunction are: (1) In T lymphocytes, the C_4 subpopulation with auxiliary and inductive effects is significantly lower than that in normal subjects, while the total number of T lymphocytes in peripheral blood is significantly decreased, while the CD_3 subpopulation with inhibitory and cytotoxic functions Significantly higher than normal. These changes were significantly associated with serum creatinine (Scr) values and were the result of immunosuppressive effects in serum uremic toxins. In addition, moderate and severe malnutrition can also cause these changes. ② uremia, granulocyte glucose metabolism disorders, exercise and phagocytic response impaired. ⑧ lack of nutrition is also an important factor. Moderate and severe malnutrition can also be caused