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对头孢唑林和头孢他啶在老年人中的药物动力学进行了研究，并同期在年轻人中进行了比较。老年组单次静滴头孢他啶１ｇ后的高峰血浓度（Ｃ_（ｍａｘ））为１０１．３６±２０．０３ｍｇ／Ｌ，血清消除半衰期（Ｔ_（１／２β））为２．４２±０．３４ｈ，肾清除率（Ｃｌｒ）为６２．９３±１９．２１ｍｌ／ｍｉｎ，药一时曲线下面积（ＡＵＣ）为２４４．３０±６１．５１ｈ·ｍｇ／Ｌ。与年轻组相比，血清Ｔ_（１／２β）延长，Ｃｌｒ降低，ＡＵＣ增大，两者间的差异具统计学显著意义（Ｐ＜０．０１）；Ｃ_（ｍａｘ）则相近。老年组单次静滴头孢唑林后，血清Ｔ_（１／２β）也较年轻者为长，分别为２．４８±０．３７和１．９４±０．２６ｈ；Ｃｌｒ为低，分别为３４．６８±７．１０和４４．５３±１０．９６ｍｌ／ｍｉｎ；ＡＵＣ增大，分别为３８０．７１±６１．３９和３３９．５６±７９．８９ｈ·ｍｇ／Ｌ，上述药动参数间的差异除ＡＵＣ外均具统计学意义（Ｐ＜０．０５）。根据本研究结果，提出头孢他啶和头孢唑林在治疗老年人感染时的给药调整方案。
Pharmacokinetics of cefazolin and ceftazidime in the elderly were studied and compared among younger adults over the same period. In the elderly group, the peak blood concentration (C max) after single intravenous ceftazidime was 101.36 ± 20.03 mg / L and the serum elimination half-life (T 1/2 1/2) was 2.42 ± 0.34 h, The renal clearance rate (Clr) was 62.93 ± 19.21ml / min, and the area under the curve of instantaneous dose (AUC) was 244.30 ± 61.51h · mg / L. Compared with the young group, serum T 1/2 (1/2) prolonged, Clr decreased, AUC increased, the difference between the two groups was statistically significant (P <0.01); C max was similar. After single intravenous cefazolin, the serum T 1/2 (1/2) in the elderly group was longer than that of the younger ones (2.48 ± 0.37 and 1.94 ± 0.26 hours, respectively); Clr was low, 34 .68 ± 7.10 and 44.53 ± 10.96ml / min, respectively; AUC increased, respectively, 380.71 ± 61.39 and 339.56 ± 79.89h · mg / L, the difference between the above pharmacokinetic parameters Except for AUC with statistical significance (P <0.05). According to the results of this study, we proposed the adjustment of ceftazidime and cefazolin in the treatment of elderly infections.