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目的：观察克拉霉素与美满霉素对男性非林菌性尿道炎（NGU）的疗效及毒副作用。方法：对确诊的79例NGU患者，随机分为克拉霉素组40例（简称A组）和美满霉素组39例（简称B组）。沙眼衣原作（CT）用PCR检测，解脲支原体（UU）与淋球菌（NG）用培养检测。结果：A组与B组的治愈率、总有效率和毒副作用率分别是：95．0％、100％、10．0％与61．5％、89．7％、56．4％，两组治愈率及毒副作用率差异有显著性（P均＜0．01），总有效率差异无显著性（P＞0．05）。结论：克拉霉素治疗男性NGU优于美满霉素。
Objective: To observe the curative effect and toxicity of clarithromycin and minocycline on male non-mycotic urethritis (NGU). Methods: 79 confirmed cases of NGU were randomly divided into clarithromycin group 40 cases (referred to as A group) and minocycline 39 cases (referred to as group B). Trachoma clothing (CT) with PCR detection, Ureaplasma urealyticum (UU) and Neisseria gonorrhoeae (NG) culture detection. Results: The cure rate, total effective rate and toxic side effects of group A and group B were 95.0%, 100%, 10.0% and 61.5%, 89.7% and 56.4% There were significant differences in cure rate and toxic side effects between the two groups (all P <0.01). There was no significant difference in the total effective rate (P> 0.05). Conclusion: Clarithromycin is superior to minocycline in the treatment of male NGU.