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虽然各型麻风中巨噬细胞有差异的确切原因还不清楚,但某些因素如遗传、功能变异、表面膜改变和T细胞特异致敏作用不足等可能与此有关。作者在经过不同处理的小鼠足垫中感染麻风杆菌之后,研究了它们的腹膜巨噬细胞的吞噬和杀菌能力。小鼠分为4组:(1)正常小鼠对照组(NC);(2)正常小鼠感染组(NI);(3)胸腺摘除并经照射的小鼠的对照组(TRC)和(4)胸腺切除加照射的感染小鼠组(TRI)。小鼠在足垫中接种菌后3个月开始检查,巨噬细胞的吞噬能力用细胞总数中吞噬2
Although the exact cause of macrophages in each type of leprosy is unclear, some factors such as genetic, functional variation, alterations in the surface membrane, and insufficient T cell-specific sensitization may be related to this. The authors studied the phagocytosis and bactericidal activity of their peritoneal macrophages after they infected M. leprae in foot pads of differently treated mice. The mice were divided into four groups: (1) normal mouse control group (NC); (2) normal mouse infection group (NI); (3) TRC and 4) Thyotectomy plus irradiated infected mice group (TRI). Mice in foot pad inoculation after 3 months began to check macrophages phagocytosis with the total number of cells phagocytosis 2