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应用双抗体夹心ELISA法测定110例宫颈上皮增生病变和30例宫颈癌患者TNFα、sIL-2R、IL-6和IL-8的含量。结果:宫颈上皮增生病变各组患者TNFα、sIL-2R、IL-6和IL-8水平均明显高于对照组(均P<0.01),且随宫颈上皮病变程度的加重而相应地升高。宫颈癌组细胞因子变化的特点:(1)TNFα和sIL-2R水平增高显著,与宫颈上皮内瘤样病变(CIN)各病变组有明显差异(均P<0.01)。(2)IL-6和IL-8水平未见明显改变。表明细胞因子的变化与宫颈上皮增生病变的进展以及宫颈癌患者的免疫抑制状态相关。因此,细胞因子的测定对于宫颈癌的早期辅助诊断和预后的判断有重要的临床意义。
The levels of TNFα, sIL-2R, IL-6 and IL-8 in 110 cases of cervical epithelial hyperplasia and 30 cases of cervical cancer were detected by double antibody sandwich ELISA. Results: The levels of TNFα, sIL-2R, IL-6 and IL-8 in patients with cervical epithelial hyperplasia were significantly higher than those in control group (all P <0.01), and increased with the severity of cervical epithelial lesions. The characteristics of cytokines in cervical cancer group were as follows: (1) The levels of TNFα and sIL-2R increased significantly, which were significantly different from those of cervical intraepithelial neoplasia (CIN) (all P <0.01). (2) IL-6 and IL-8 levels did not change significantly. The changes of cytokines are related to the progress of cervical epithelial hyperplasia and the immunosuppressive status of cervical cancer patients. Therefore, the determination of cytokines for cervical cancer early diagnosis and prognosis of adjuvant has important clinical significance.