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新生儿病房１９８９年１０月～１９９０年１２月、１９９６年３～６月两个时间段分离４０株铜绿假单胞菌，血清学分型率９７．５％，第一时间段以Ｏ１１型最多，占３０．４％，集中在１９９０年６～１０月，第二时间段Ｏ３型占９３．８％，集中在１９９６年３～６月，表明该病房发生两次铜绿假单胞菌医院感染流行。质粒检出率４２．９％，Ｏ１１型菌株质粒谱为８．１、４６．５、１７９．１ｋｂ，并经ＨｉｎｄⅢ酶切进一步证实为同一克隆。对氟哌酸、阿米卡星及头孢他啶的敏感率分别为１００％、９７．３％和９５％。对庆大霉素耐药率明显上升，提示控制铜绿假单胞菌医院感染的重要性。
40 strains of Pseudomonas aeruginosa isolated from October 1989 to December 1990 and from March to June 1996, the serological typing rate was 97.5%. The first time period was O11 type, Accounting for 30.4%, concentrated in June to October 1990, the second time period accounted for 93.8% O3 type, concentrated in March to June 1996, indicating that ward occurred twice in the epidemic of Pseudomonas aeruginosa nosocomial infections . The positive rate of plasmid was 42.9%. The plasmid of O11 strain was 8.1, 46.5 and 179.1 kb, which was confirmed by Hind Ⅲ digestion. The sensitivity to norfloxacin, amikacin and ceftazidime were 100%, 97.3% and 95%, respectively. The resistance rate to gentamicin increased significantly, suggesting the importance of controlling Pseudomonas aeruginosa nosocomial infection.