迄今为止,ｐ53基因仍是已发现的最重要的抑癌基因,它的失活常导致肿瘤的发生,约50%的实体瘤有ｐ53基因的缺失和(或)点突变,在恶性血液病中ｐ53基因的变化虽不是普遍现象,但和疾病的进展与耐药密切相关,我们已经报道了61例白血病ｐ53基因的变化,现将对恶性淋巴瘤研究的结果报道 To date, the p53 gene remains the most important tumor suppressor gene that has been discovered. Its inactivation often leads to tumorigenesis. About 50% of solid tumors have a p53 gene deletion and / or point mutation. In the case of hematologic malignancies Although the change of p53 gene is not a common phenomenon, it is closely related to the progress of the disease and resistance. We have reported the changes of p53 gene in 61 cases of leukemia. The results of the study on malignant lymphoma will now be reported