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目的研究人体性激素水平变化与原发性肝细胞癌的关系．方法应用放免法测定肝癌组（２０例），肝硬变组（１６例）及正常对照组（２０例）血清雌二醇（Ｅ２）及睾酮（ＴＴＴ）含量，并用放免组化法（ＰＡＰ法）检测肝癌组织及肝硬变组织的雌二醇受体（ＥＲ）及睾酮受体（ＡＲ）含量．结果肝癌组血清Ｅ２含量（４４５５±９３１ｎｇ／Ｌ）明显高于正常对照组（７６６ｎｇ／Ｌ±１７０ｎｇ／Ｌ）而低于肝硬变组（６４９６ｎｇ／Ｌ±１７６ｎｇ／Ｌ）（Ｐ＜００１）；前者ＴＴＴ含量（２５３３００ｎｇ／Ｌ±５６５６０ｎｇ／Ｌ）明显低于后二者（４５８５８０ｎｇ／Ｌ±３４９６０ｎｇ／Ｌ）（Ｐ＜００１）．肝癌组织ＥＲ（８０％）较肝硬变时（４４％）明显增加（Ｐ＜００２５），且与血清Ｅ２含量有明显负相关关系（ｒ＝－０８４７３，Ｐ＜０００１）．ＡＲ阳性百分率在两者无明显差别（ｒ＝－０３１３５，Ｐ＞００５）．结论血清ＴＴＴ含量改变及肝组织ＡＲ浓度改变与肝癌无明显关系，而血清Ｅ２含量改变及肝组织ＥＲ浓度改变与肝癌的发生、发展有密切关系．提示原发性肝细胞癌是一雌激素依赖性肿瘤．
3. Objective To study the relationship between human sex hormone levels and primary hepatocellular carcinoma. Methods The levels of serum estradiol (E2) and testosterone (TTT) in liver cancer group (20 cases), cirrhosis group (16 cases) and normal control group (20 cases) were measured by radioimmunoassay, and radioimmunoassay (PAP method) was used. ) Detection of estradiol receptor (ER) and testosterone receptor (AR) content in hepatocellular carcinoma and cirrhosis. Results The serum E2 content in HCC group (4455±931ng/L) was significantly higher than that in the normal control group (766ng/L±170ng/L) and lower than that in the cirrhosis group (6496ng/L±). 176ng/L) (P<001); The former TTT content (253300ng/L±56560ng/L) was significantly lower than the latter two (458580ng/L±34960ng/L) ( P<001). ER (80%) in hepatocellular carcinoma was significantly higher than that in cirrhosis (44%) (P<0025), and there was a significant negative correlation with serum E2 content (r=-08473, P<0001). . There was no significant difference in AR positive percentage (r=-03135, P>005). Conclusion The change of serum TTT and the change of liver tissue AR concentration are not significantly related to HCC. The change of serum E2 and the change of liver ER concentration are closely related to the occurrence and development of HCC. It suggests that primary hepatocellular carcinoma is an estrogen-dependent tumor.