论文部分内容阅读
目的探讨IGF-Ⅱ在不明原因不孕患者胚胎着床窗口期子宫内膜中的表达及其与不孕的关系。方法通过单克隆抗体SP免疫组化法检测不明原因不孕患者胚胎着床窗口期子宫内膜IGF-Ⅱ的表达。结果子宫内膜IGF-Ⅱ表达定位于胞浆,腺体强于间质。不明原因不孕患者组子宫内膜腺体H-score值142.73±24.85,间质106.03±25.30:对照组腺体H-score值165.70±19.42,间质126.10±21.22。两组间差异显著(p<0.05)。结论胚胎着床窗口期子宫内膜局部IGF-Ⅱ表达下降,可能是引起不明原因不孕的病因之一。
Objective To investigate the expression of IGF-Ⅱ in the endometrium of embryo implantation window and its relationship with infertility in patients with unexplained infertility. Methods Immunohistochemical SP method was used to detect the expression of IGF-Ⅱ in endometrium of embryo implantation window in patients with unexplained infertility. Results The expression of endometrial IGF-Ⅱ localized in cytoplasm, gland was stronger than interstitial. The H-score of endometrial glands in unexplained infertility patients was 142.73 ± 24.85, and the interstitial was 106.03 ± 25.30: the H-score of control glands was 165.70 ± 19.42, and the quality of the stroma was 126.10 ± 21.22. There was significant difference between the two groups (p <0.05). Conclusion The expression of IGF-Ⅱ in endometrium of embryo implantation window may be one of the causes of unexplained infertility.