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目的:观察穴位贴敷联合西药治疗溃疡性结肠炎(UC)患者的临床疗效。方法:将69例溃疡性结肠炎患者随机分成治疗组35例和对照组34例,治疗组患者采用药物穴位敷贴联合西药治疗,对照组患者采用单纯西药治疗,比较两组患者总有效率及血清IL-4、IL-6、IL-8、IL-10、TNF-α水平。结果:治疗组患者临床总有效率、缓解率分别为91.43%、71.43%,分别高于对照组的70.59%、44.11%,差异具有统计学意义(P分别为0.027、0.022);治疗后两组患者IL-4、IL-10水平均升高,IL-6、IL-8、TNF-α水平均降低,且治疗组患者各指标改善情况更显著,差异具有统计学意义(P<0.05)。结论:穴位贴敷联合西药治疗溃疡性结肠炎患者的临床疗效较常规西药显著,其作用机制可能与调节炎症因子平衡有关。
Objective: To observe the clinical efficacy of acupoint sticking combined with western medicine in the treatment of patients with ulcerative colitis (UC). Methods: Sixty-nine patients with ulcerative colitis were randomly divided into treatment group (n = 35) and control group (n = 34). The patients in the treatment group were treated with drug acupoint sticking combined with western medicine, while the control group were treated with western medicine alone. The total effective rate Serum IL-4, IL-6, IL-8, IL-10, TNF-α levels. Results: The total clinical effective rate and remission rate in the treatment group were 91.43% and 71.43%, respectively, which were higher than those in the control group (70.59% and 44.11%, respectively) (P = 0.027 and 0.022, respectively) The levels of IL-4 and IL-10 in patients were increased, the levels of IL-6, IL-8 and TNF-α were decreased, and the improvement of each index was more significant in the treatment group, the difference was statistically significant (P <0.05). Conclusion: Acupoint sticking combined with Western medicine in the treatment of patients with ulcerative colitis clinical efficacy than conventional Western medicine significantly, the mechanism may be related to the regulation of inflammatory cytokines balance.