目的探讨立体定向活检对颅内原发性黑色素瘤的诊断价值及与伽玛刀相结合治疗的疗效。方法对1例影像学上诊断不明确的颅内病灶行立体定向活检,明确病理性质后行伽玛刀治疗后随访,并复习相关文献。结果对本例患者行颅内病灶行立体定向活检后送病理检查明确诊断颅内病灶为黑色素细胞瘤,且病灶体积缩小、肿瘤实质部分集中,伽玛刀治疗效果良好。结论立体定向活检对明确诊断颅内原发性黑色素瘤有重要价值,联合伽玛刀治疗的疗效显著。 Objective To investigate the value of stereotactic biopsy in the diagnosis of intracranial primary melanoma and its efficacy in combination with gamma knife. Methods One case of intracranial lesions with unclear diagnosis was treated with stereotactic biopsy. The pathological features were determined and followed up by gamma knife. The related literatures were reviewed. Results of this case of patients with intracranial lesions stereotactic stereotactic biopsy after the pathological examination of a clear diagnosis of intracranial lesions of melanocytoma, and lesion size reduced, the tumor part of the focus, the gamma knife treatment is good. Conclusion Stereotactic biopsy has a significant value in the diagnosis of primary intracranial melanoma, and the effect of gamma knife treatment is significant.