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目的 观察脑出血（ＣＨ）、脑梗死（ＣＩ）、蛛网膜下腔出血（ＳＡＨ）患者血浆神经降压素（ＮＴ）水平改变及其动态变化。方法 选择ＣＨ组４６例、ＣＩ组６２例、ＳＡＨ组３０例，用放免法检测血浆ＮＴ浓度。结果ＣＩ组、ＣＨ组、ＳＡＨ组ＮＴ水平均显著高于对照组，于发病后２４小时内显著升高，１～３天或４～７天达高峰，８～１５天开始下降，１５天后仍在较高水平；随病情加重与病灶扩大显著升高；ＣＩ与ＣＨ伴高血糖组均显著高于正常血糖组，ＣＨ伴高血压组、伴消化道出血组显著高于正常血压组与无消化道出血组。ＳＡＨ组伴ＤＩＤ组明显高于非ＤＩＤ组。结论 ＮＴ分泌异常参与了ＣＩ、ＣＨ、ＳＡＨ的病理生理过程。
Objective To observe the changes of plasma neurotensin (NT) levels and their dynamic changes in patients with cerebral hemorrhage (CH), cerebral infarction (CI) and subarachnoid hemorrhage (SAH). Methods 46 cases of CH group, 62 cases of CI group, 30 cases of SAH group, the plasma concentration of NT was detected by radioimmunoassay. Results The levels of NT in CI group, CH group and SAH group were significantly higher than those in control group, significantly increased within 24 hours after onset, peaked at 1-3 days or 4-7 days, decreased at 8-15 days and remained unchanged after 15 days At the higher level; with the increase of the disease and the lesions enlarged significantly; CI and CH with hyperglycemia were significantly higher than the normal blood glucose group, CH with hypertension group, with gastrointestinal bleeding group was significantly higher than the normotensive group and without digestion Road bleeding group. SAH group with DID group was significantly higher than non-DID group. Conclusion Abnormal NT secretion is involved in the pathophysiological processes of CI, CH and SAH.