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目的研究ｎｍ２３基因产物与肺癌临床病理间的关系。方法应用ＳＡＢＣ免疫组化法，检测６９例肺癌中ｎｍ２３基因产物二磷酸核苷激酶（ＮＤＰＫ）的表达情况。结果ｎｍ２３在肺癌中有较高表达，阳性率７９．７％（５５／６９），其中鳞癌１００％（３１／３１），腺癌７１．４％（２０／２８），小细胞癌４０％（４／１０），在鳞癌中的表达较腺癌及小细胞癌高（ｐ＜０．０５）。但ｎｍ２３的表达与肺鳞癌的分化程度无关（ｐ＞０．０５），与肺鳞癌、肺腺癌及其它肺癌有无肺门或纵隔淋巴结转移无关（ｐ＞０．０５）。结论提示肺癌的形成和转移与多基因、多步骤的遗传学改变有关，应将ｎｍ２３基因与其他因素进行同时研究，以准确反映肺癌恶性生物学行为的重要特点。
Objective To study the relationship between nm23 gene products and clinical pathology of lung cancer. Methods SABC immunohistochemical method was used to detect the expression of nm23 gene product nucleoside diphosphate kinase (NDPK) in 69 cases of lung cancer. Results nm23 was highly expressed in lung cancer, with a positive rate of 79.7% (55/69), including 100% (31/31) of squamous cell carcinoma, 71.4% (20/28) of adenocarcinoma, and 40% of small cell carcinoma. (4/10) The expression in squamous cell carcinoma was higher than that in adenocarcinoma and small cell carcinoma (p<0.05). However, the expression of nm23 was not related to the degree of differentiation of lung squamous cell carcinoma (p>0.05), but had nothing to do with lung squamous cell carcinoma, lung adenocarcinoma and other lung cancer with or without hilar or mediastinal lymph node metastasis (p>0.05). Conclusions suggest that the formation and metastasis of lung cancer are related to the multi-gene and multi-step genetic changes. The nm23 gene and other factors should be studied simultaneously to accurately reflect the important features of malignant biological behavior of lung cancer.