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临床上呼吸窘迫综合征(RDS)死亡率高,原因是发病机理不明。近年认为中性粒细胞(PMN)具有重要意义。最近有人提出肺泡巨噬细胞(PAM)作用更为重要。本文试通过研究实验性RDS时PAM的糖皮质激素受体(GCR)的变化,探讨其在RDS发病学中的作用。 健康成年雄兔26只(1.8～2.5kg),对照组10只,实验组16只。实验组动物耳缘静脉注射油酸(0.14ml/kg),复制RDS模型,观察2～4小时内呼吸,PaO_2、PaCO_2、pH的动态变化以判
Clinically, respiratory distress syndrome (RDS) mortality is high because the pathogenesis is unknown. In recent years, neutrophils (PMN) is of great significance. Recently it was suggested that the role of alveolar macrophages (PAM) is more important. This article attempts to explore the role of PAM in glucocorticoid receptor (GCR) in experimental RDS to study the pathogenesis of RDS. Twenty-six healthy adult male rabbits (1.8-2.5kg), 10 in the control group and 16 in the experimental group. In the experimental group, oleic acid (0.14ml / kg) was injected into the ear vein of the experimental group, and the RDS model was duplicated. The dynamic changes of respiration, PaO_2, PaCO_2 and pH within 2 ~ 4 hours were observed