论文部分内容阅读
目的 探讨细胞凋亡与外阴硬化苔癣型营养不良发病的关系。方法 采用原位末端标记法（ 反映细胞的凋亡情况） 和增殖细胞核抗原检测（ 反映细胞的增殖活性） ， 对３６ 例外阴硬化苔癣型营养不良及１０ 例正常皮肤进行原位观察。结果 外阴硬化苔癣型营养不良表皮各层细胞中均出现细胞凋亡的形态和生物特征。基底层增殖细胞下降。结论 表皮细胞凋亡构成了外阴硬化苔癣型营养不良发生的病理学基础
Objective To investigate the relationship between apoptosis and the pathogenesis of lichen-type malnutrition in vulvar vulva. Methods 36 cases of lichenoid vulvar lichen sclerosis and 10 normal skin were observed by in situ end labeling (which reflects the apoptosis of cells) and proliferating cell nuclear antigen (which reflect the proliferative activity of cells). Results The morphology and biological characteristics of apoptotic cells in all layers of epidermis of vulva vulgaris lichen-type malnutrition were observed. Basal layer of proliferating cells decreased. Conclusion Epidermal cell apoptosis constitutes the pathological basis for the occurrence of lichen-type malnutrition in vulvar vulva