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目的了解某儿童医院住院患儿药敏现状,为临床合理用药提供资料。方法统计湖南省郴州市第一人民医院儿童医院2007～2009年住院患儿5种检出菌对19种抗菌药物药敏试验结果并与其他地区比较。结果大肠埃希菌、肺炎克雷伯菌、嗜麦芽窄食假单胞菌对氨苄西林、氨苄西林-舒巴坦、头孢噻吩、头孢呋辛、头孢噻肟敏感率均低于20%,对头孢哌酮、头孢他啶、环丙沙星、阿米卡星、复方甲基异恶唑、氯霉素敏感率介于20%～95%之间,大肠埃希菌、肺炎克雷伯菌对亚胺培南敏感率大于96%,嗜麦芽窄嗜假单胞菌对亚胺培南敏感率为0;金黄色葡萄球菌对青霉素、克林霉素敏感率低于20%,对万古霉素、利福平敏感率高于85%,对头孢呋辛、头孢噻肟、四环素、庆大霉素敏感率介于60%～90%之间;肺炎链球菌对头孢呋辛、头孢噻肟、万古霉素敏感率大于85%,对青霉素、苯唑西林、克林霉素、四环素敏感率介于40%～75%之间。结论要加强临床分离菌对抗菌药物的敏感性监测。
Objective To understand the status of drug susceptibility in hospitalized children in a children’s hospital and provide information for clinical rational drug use. Methods The results of drug susceptibility testing of five kinds of antibiotics in five kinds of in-hospital children from 2007 to 2009 in Children’s Hospital of Chenzhou First People’s Hospital of Hunan Province were statistically compared with other areas. Results The susceptibilities of Escherichia coli, Klebsiella pneumoniae and Pseudomonas maltophilia to ampicillin, ampicillin-sulbactam, cefalotin, cefuroxime and cefotaxime were all less than 20% Cefoperazone, ceftazidime, ciprofloxacin, amikacin, compound methylisoxazole, chloramphenicol susceptibility between 20% to 95%, Escherichia coli, Klebsiella pneumoniae in Asia Amine peramine sensitivity was greater than 96%, Stenotrophomonas maltophilia sensitive to imipenem was 0; Staphylococcus aureus penicillin, clindamycin susceptibility less than 20% of vancomycin, The sensitivity of rifampicin was higher than 85%, and the susceptibility rate to cefuroxime, cefotaxime, tetracycline and gentamycin was between 60% and 90%. Streptococcus pneumoniae was sensitive to cefuroxime, cefotaxime and eternal The susceptibility rate of mycophenol was more than 85%. The susceptibilities to penicillin, oxacillin, clindamycin and tetracycline ranged from 40% to 75%. Conclusion The sensitivity of clinical isolates to antimicrobial agents should be monitored.