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目的:利用弥散张量成像技术研究额叶挫裂伤患者慢性期的白质结构改变情况,探讨额叶挫裂伤患者运动功能损伤的机制。方法:15例慢性期额枕叶对冲伤患者与21例对照组纳入本研究,采用格拉斯哥预后评分评估患者运动能力,使用Track Vis&Diffusion Toolkit软件获得FA参数图并进行纤维素示踪,对参数图进行全脑范围逐体素的统计。结果:与健康对照组比较,慢性额叶挫裂伤患者表现为全脑广泛性的FA值下降,主要集中在额、枕、颞叶的灰白质,胼胝体,小脑白质和脑深部白质,感兴趣区的研究结果表明,皮质脊髓束的完整性遭到破坏。结论:额叶挫裂伤患者在全脑范围内出现广泛的白质结构损伤,这些脑区的损伤可能是额叶挫裂伤患者的运动功能损伤的机制。
OBJECTIVE: To study the changes of white matter structure in chronic phase of frontal lobe contusion and laceration by diffusion tensor imaging and to explore the mechanism of motor function impairment in frontal lobe contusion. Methods: Fifteen patients with chronic occipital lobe and 21 controls were enrolled in this study. The Glasgow prognostic score was used to assess the patient’s motor ability. The FA parameter map was obtained with the aid of the Track Vis & Diffusion Toolkit software and subjected to cellulose tracing. Whole-brain-by-voxel statistics. Results: Compared with the healthy control group, the patients with chronic frontal lobe contusion showed a decline in the FA value of the whole brain, mainly in the white matter of the frontal, occipital and temporal lobe, corpus callosum, white matter of the cerebellar white matter, and deep brain white matter. Regional findings suggest that the integrity of the corticospinal tract is compromised. CONCLUSION: Extensive white matter structural damage occurs in the frontal lobe contusion in patients with frontal lobe laceration. The damage of these brain regions may be the mechanism of motor function impairment in frontal lobe contusion patients.