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合成了2种含有二硫吡啶结构的原子转移自由基聚合(ATRP)引发剂,ATRP引发剂结构采用核磁共振氢谱(1H-NMR)表征.结果显示,二硫吡啶结构被成功引入引发剂结构末端或链中间.利用2种ATRP引发剂分别制备了链末端功能化和链中间功能化的聚N,N-二乙基丙烯酰胺(pDEAAm).采用1H-NMR和凝胶渗透色谱(GPC)对聚合物结构和分子量进行了表征.1H-NMR结果显示,二硫吡啶基团被引入聚合物链末端或中间.GPC结果表明,末端功能化和中间功能化的聚N,N-二乙基丙烯酰胺(pDEAAm)分子量分布指数分别为1.21和1.23,实现了分子量的可控聚合.并且,具有2个引发位点的引发剂引发单体得到聚合物的分子量较大.采用紫外-可见分光光度法研究了聚合物在溶液中的温度响应性.紫外-可见分光光度法结果说明,pDEAAm溶液在28°C发生相分离,在溶液中表现出温度响应性,且最低临界溶解温度(LCST)为28°C.在末端功能化和中间功能化温敏型pDEAAm可用于嵌段共聚物的合成以及与生物大分子的定位结合.特别对于中间功能化的pDEAAm,有望用于星型聚合物和多臂聚合物的设计和制备.
Two kinds of ATRP initiators were synthesized and the structure of ATRP initiator was characterized by 1H-NMR. The results showed that the disulfopyridine structure was successfully introduced into the initiator structure Terminal or in the middle of the chain.The chain-terminal functionalized and chain-functionalized poly (N, N-diethylacrylamide) (pDEAAm) were prepared by two kinds of ATRP initiator.Using1H-NMR and gel permeation chromatography (GPC) The structure and molecular weight of the polymer were characterized.1H-NMR results showed that the dithiopyridine group was introduced into the polymer chain at the end or in the middle.GPC results showed that the terminal functionalized and intermediate functionalized poly N, N-diethyl Acrylamide (pDEAAm) molecular weight distribution index of 1.21 and 1.23, respectively, to achieve a controlled polymerization of molecular weight and initiator with two initiator sites to give the monomer to obtain a larger molecular weight polymer using UV - Visible spectrophotometry Method was used to study the temperature responsiveness of the polymer in solution.Ultraviolet-visible spectrophotometry results showed that the phase separation of pDEAAm solution at 28 ° C showed temperature responsiveness in solution and the lowest critical solution temperature (LCST) was 28 ° C. At the end of work And intermediate functionalization Temperature-sensitive pDEAAm can be used for the synthesis of block copolymers and for the localization of biological macromolecules, especially for intermediate functionalized pDEAAm, which is expected to be used in the design and preparation of star polymers and multi-armed polymers .