感染日本血吸虫的小鼠一次口服吡喹酮300mg/kg后0.5小时,雄虫体表皮层即有不同程度的水肿、空泡样变化和空泡破裂,继则有细絮状物或絮状团块粘附在受损的体表或抱雌沟内。给药6小时后即见有白细胞附着在受损的皮层上,12小时后则已有白细胞侵入虫体。雌虫体表皮层的损害和出现白细胞附着与侵入虫体的时间较雄虫为迟。此外,对血吸虫经吡喹酮作用后,其皮层的损害和白细胞的附着与侵入虫体的意义进行了一些讨论。 In mice infected with Schistosoma japonicum, oral administration of praziquantel 300mg / kg for 0.5 hours resulted in different degrees of edema, vacuolar changes and vacuolar rupture in the male epidermis, followed by fine flocculent or flocculent Block adhesion in the damaged body surface or hold the female groove. Six hours after administration, leukocytes adhered to the damaged cortex and leukocytes invaded into the worms 12 hours later. The damage of female epidermis and the appearance of leucocyte attachment and invasion of parasites were later than that of male. In addition, the parasitic schistosomiasis praziquantel role, the damage of the cortex and leukocyte attachment and invasion of parasites significance.