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抗焦虑剂(如乙醇、巴比妥类、苯二氮杂(艹卓))停用后常可引起撤药症状,轻者表现为焦虑、烦燥不安、感知障碍,重者表现为谵妄和抽搐发作。撤药症状的出现率及严重程度和持续时间因药物种类不同而有差别。GABA 是哺乳动物 CNS 中重要的抑制性神经递质。能够提高脑内 GABA 浓度的药物具有镇静和抗抽搐作用。现在日益证明,抗焦虑剂主要通过 GABA—苯二氮杂(艹卓)受体的复合体的机制来促进 CNS 中 GABA 的传递。突触后 GABA 受体与特殊的苯二氮杂(艹卓)
Anti-anxiety agents (such as ethanol, barbiturates, benzodiazepines) can often cause withdrawal symptoms after discontinuation, the light was the performance of anxiety, irritability, cognitive impairment, severe cases showed delirium and Twitch attack. The withdrawal symptoms and the severity and duration of the withdrawal symptoms vary depending on the type of drug. GABA is an important inhibitory neurotransmitter in mammalian CNS. Drugs that increase the concentration of GABA in the brain have sedative and anticonvulsant effects. It is now increasingly proven that anxiolytic agents promote the delivery of GABA in the CNS primarily through a complex of GABA-benzodiazepine receptors. Post-synaptic GABA receptor and a special benzodiazepine (艹 Zhuo)