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本文比较新、老两种不同路线合成的dl-15甲基前列腺素(简称PG)F_(2α)甲酯长效栓单次阴道用药,配伍丙酸睾丸酮(简称丙睾)或光学活性18甲基三烯炔诺酮(简称23号)的抗早孕效果。360例有效率达93.61%,其中完全流产率85%,不全流产率8.61%,失败率6.39%。结果表明,新老两种工艺合成前列腺素抗早孕效果并无显著差异(P>0.05),但新工艺的成本远较老工艺低。两种配伍方案的效果虽无显著差异(P>0.05),但服用23号孕妇有19.3%发生一过性肝损,提示新工艺合成的dl-15甲基PGF_(2α)甲酯配伍丙睾,效果更佳。
This article is relatively new, old two different routes synthetic dl-15 methyl prostaglandin (referred to PG) F 2α methyl ester long-acting suppository single vaginal medication, with testosterone propionate (or testosterone) or optically active 18 A The effect of antihypertensive effect of nadino-norethindrone (abbreviated as No. 23). 360 cases of effective rate of 93.61%, of which 85% of complete abortion, incomplete abortion rate of 8.61%, the failure rate of 6.39%. The results showed that there was no significant difference (P> 0.05) between the new and the old synthetic prostaglandin anti-early pregnancy effects, but the cost of the new process was much lower than that of the old one. Although there was no significant difference between the two regimens (P> 0.05), 19.3% of 23 pregnant women had transient hepatic damage, suggesting that the new synthetic methyl-2-methyl-PGF_ (2α) , The effect is better.