目的　探讨血管紧张素转换酶 (ACE)基因多态性与妊高征 (PIH)的关系。方法　 2 0 0 0年 5月至 2 0 0 3年 5月 ,运用多聚酶链反应技术检测 99例PIH及 5 4例对照组的ACE基因多态性。结果　PIH患者ACE基因II、ID、DD基因型频率分别为 2 0 2 %、37 4 %、4 2 4 % ,对照组II、ID、DD基因型频率分别为 4 4 4 %、2 9 6 %、2 5 9% ;两组的DD基因型及D等位基因频率比较差异有显著性意义 ;中、重型组DD基因型与轻型组相比差异有显著性。结论　ACE基因多态性与PIH的发病有关 ,且与PIH病情严重程度有关 Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and pregnancy induced hypertension (PIH). Methods From May 2000 to May 2003, polymerase chain reaction (PCR) was used to detect ACE gene polymorphism in 99 cases of PIH and 54 cases of control group. Results The frequency of genotypes II, ID and DD of ACE gene in PIH patients were 202%, 374% and 424% respectively. The frequencies of genotypes II, ID and DD in control group were 44.4% and 296% , 259% respectively. There was significant difference in DD genotype and D allele frequency between the two groups. There was significant difference between DD genotypes in medium and heavy groups compared with light group. Conclusion The ACE gene polymorphism is associated with the pathogenesis of PIH and is related to the severity of PIH