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目的探讨早期肠内营养和肠外营养支持对早期胃癌切除术后患者的影响。方法选取早期胃癌切除术后患者120例,按照随机数字表法将患者随机分为治疗组和对照组,每组各60例。治疗组患者给予肠内营养支持,对照组患者给予肠外营养支持,干预周期为7 d。结果与治疗组患者比较,营养支持后对照组患者血清总胆红素、丙氨酸氨基转移酶和门冬氨酸氨基转移酶值明显升高,差异有统计学意义(P<0.05)。营养支持后,两组患者血清前白蛋白、血清血蛋白、CD+3和CD+4值明显升高,差异均有统计学意义(均P<0.05)。随访3个月,治疗组患者的切口感染、心胸腔积液、肺部感染、吻合口漏等并发症的总发生率明显小于对照组患者,差异有统计学意义(P<0.05)。结论肠内营养支持能促进早期胃癌切除术后患者免疫功能和机体营养状况的恢复,对患者的肝功能损害小,安全性更好,值得临床推广应用。
Objective To investigate the effect of early enteral nutrition and parenteral nutrition on patients after early gastric cancer resection. Methods One hundred and twenty patients with early gastric cancer were selected. According to the random number table, the patients were randomly divided into treatment group and control group, with 60 cases in each group. Enteral nutrition was given to the patients in the treatment group and parenteral nutrition was given to the patients in the control group. The intervention period was 7 days. Results Compared with the patients in the treatment group, the levels of serum total bilirubin, alanine aminotransferase and aspartate aminotransferase in patients in the control group after nutrition support were significantly increased (P <0.05). After nutritional support, serum prealbumin, serum albumin, CD + 3 and CD + 4 were significantly increased in both groups (all P <0.05). The follow-up of 3 months, the incidence of incision infection, cardiothoracic effusion, pulmonary infection, anastomotic leakage and other complications in the treatment group was significantly less than that in the control group, the difference was statistically significant (P <0.05). Conclusions Enteral nutrition support can promote the immune function and the recovery of nutritional status of patients after resection of gastric cancer. It is less harmful to patients with liver function and has better safety. It is worthy of clinical application.