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目的:探讨在频发短暂性脑缺血发作(TIA)患者中,应用抗凝治疗方案的临床疗效。方法:选取云南省交通中心医院2007年7月-2013年6月收治的频发TIA患者56例进行分析,将其随机分为对照组和观察组,每组28例。对照组采用阿司匹林治疗方案,观察组采用低分子肝素治疗方案。观察两组患者的临床治疗效果,以及疾病复发和发展为脑梗死情况。结果:观察组患者的治疗总有效率(96.4%)高于对照组(78.5%),差异具有统计学意义(P<0.05),出血风险两者对比,差异无统计学意义(P>0.05),1年内TIA复发和发展为脑梗死例数低于对照组,差异具有统计学意义(P<0.05)。结论:抗凝治疗方案在短暂性脑缺血发作患者中具有良好的效果,能减少TIA复发和控制发展为脑梗死的转归,无出血倾向,是一种安全有效的治疗方法。
Objective: To investigate the clinical efficacy of anticoagulant therapy in patients with frequent transient ischemic attack (TIA). Methods: Fifty-six patients with frequent TIA who were treated in Yunnan Provincial Communications Center Hospital from July 2007 to June 2013 were selected and randomly divided into control group and observation group, 28 cases in each group. Control group aspirin treatment program, the observation group using low molecular weight heparin treatment. To observe the clinical efficacy of two groups of patients, as well as disease recurrence and development of cerebral infarction. Results: The total effective rate (96.4%) in observation group was higher than that in control group (78.5%), the difference was statistically significant (P <0.05). There was no significant difference in bleeding risk between the two groups (P> 0.05) The number of recurrent and developing TIA in 1 year was lower in cerebral infarction than in control group, with statistical significance (P <0.05). Conclusion: The anticoagulant therapy has a good effect in patients with transient ischemic attack, which can reduce the recurrence of TIA and control the development of cerebral infarction outcome. It is a safe and effective treatment for patients with no ischemic tendency.