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应用ＥＬＩＳＡ方法及聚合酶链反应，对１８１８例孕母及其婴儿进行孕期人巨细胞病毒（ＨＣＭＶ）感染的母婴间宫内传播的前瞻性研究。结果表明：孕母ＨＣＭＶ－ＩｇＧ阳性率为８９．２％；孕母ＨＣＭＶ活动性感染率为４．５％，孕早、中、晚各期ＨＣＭＶ活动性感染率分别为２．４％、３．５％、１．９％，其中原发感染略高于１．１％，提示孕期大多数孕妇为复发感染；孕母ＨＣＭＶ抗体在孕期有阳转或阴转的不同变化；孕母不仅ＨＣＭＶ－ＩｇＭ阳性可感染胎儿，即使ＨＣＭＶ－ＩｇＧ阳性、ＩｇＭ阴性，其子仍有感染ＨＣＭＶ可能，ＨＣＭＶ－ＩｇＧ抗体对胎儿不能完全起保护作用；提示应用ＥＬＩＳＡ和ＰＣＲ技术对ＨＣＭＶ母婴传播进行诊断，对于早期干预及改善预后有极重要的作用，有必要对先天性ＨＣＭＶ感染儿进行长期随访。
A prospective study of intrauterine transmission of maternal and fetal cytomegalovirus (HCMV) infection in 1818 pregnant women and their infants during pregnancy was performed by ELISA and polymerase chain reaction (PCR). The results showed that the positive rate of HCMV-IgG in pregnant women was 89.2%, the active infection rate of HCMV in pregnant women was 4.5%, the prevalence of HCMV infection in early, middle and late pregnancy was 2.4%, 3 .5%, 1.9%, of which the primary infection slightly higher than 1.1%, suggesting that the majority of pregnant women during pregnancy is recurrent infection; pregnant mother HCMV antibody during pregnancy have positive or negative changes in different gestations; not only HCMV --IgM positive can infect the fetus, HCMV-IgG antibody may not fully protect the fetus even though HCMV-IgG is positive and IgM is negative, HCMV is still infected with HCMV; it is suggested that the diagnosis of HCMV mother-to-child transmission should be diagnosed by ELISA and PCR, For early intervention and improve prognosis have a very important role, it is necessary for long-term follow-up of children with congenital HCMV infection.