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脑膜炎实验动物模型和临床经验的报道指出,细菌性脑膜炎最适宜的抗菌治疗要依靠脑脊液(CSF)内获得的杀菌活力。CSF是脑膜炎(主要是蛛网膜下腔)感染部位的指示剂,从 CSF 清除细菌是细菌学痊愈和对此病有效的定义。本文综述β-内酰胺抗生素在治疗细菌性脑膜炎时最适当剂量的五个主要决定因素:(1)影响药物进入(穿透)
Reports from meningitis animal models and clinical trials point out that the most appropriate antibacterial therapy for bacterial meningitis depends on the bactericidal activity achieved in cerebrospinal fluid (CSF). CSF is an indicator of the site of infection in meningitis (mainly subarachnoid space) and bacterial clearance from CSF is a bacteriological definition of cure and effective for this condition. This review summarizes five main determinants of the most appropriate dose of beta-lactam antibiotics for the treatment of bacterial meningitis: (1) effects on drug entry (penetration)