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目的研究急性高原病和（或）高原性脑水肿的颅脑CT表现及其病理学基础。方法采用低压缺氧模型在模拟7000m海拔高度条件下观察家猫缺氧24、48和72小时的颅脑CT表现、脑组织毛细血管面积密度的变化及病理改变。结果CT显示脑室脑池变小或消失、脑沟变窄，大脑、基底节、脑干和小脑的密度不同程度地普遍增高；脑组织毛细血管面积密度明显增加，并与CT值呈显著直线正相关。病理学上见微血管扩张，大脑皮层神经细胞肿胀，细胞和血管周围间隙增宽，脑实质内散在广泛点状出血。结论脑肿胀可能是急性高原病和（或）高原性脑水肿的一种颅脑CT表现。
Objective To study craniocerebral CT findings and pathological basis of acute altitude sickness and / or high altitude cerebral edema. Methods Hypobaric hypoxia models were used to observe the brain CT findings at 24, 48 and 72 hours of hypoxia and the changes of capillary area density and pathological changes in the brain of cats under simulated altitude of 7000m. Results CT showed that the cerebral ventricles became smaller or disappeared and the sulci became narrower. The density of the brain, basal ganglia, brainstem and cerebellum were generally increased in varying degrees. The capillary area density of brain tissue increased significantly and showed a significant positive linear relationship with CT value Related. See pathological microvascular dilatation, cerebral cortex nerve cell swelling, widening of the gap around the cells and blood vessels, scattered within the parenchyma in a wide range of punctate bleeding. Conclusion Brain swelling may be a kind of brain CT manifestations of acute altitude sickness and / or high altitude cerebral edema.