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目的:报告精囊原发性Burkitt淋巴瘤(BL)的临床病理特征。方法:对1例精囊原发性BL的临床特征、组织学、免疫组织化学和原位分子杂交进行观察,并结合文献探讨其病理形态及鉴别诊断。结果:本例临床表现以尿频和排尿困难为特征,发病2个月后出现腹股沟淋巴结肿大。影像学显示病灶精囊呈低密度阴影,组织学呈弥漫单一性中等大小肿瘤细胞浸润性生长伴肿瘤性坏死,核分裂易见并有“星空”图象。免疫标记肿瘤细胞表达CD10、CD20、CD79α和Bcl-6,而CD3、CD5、CD23、MPO、Bcl-2、CyclinD1和TdT缺乏表达,肿瘤细胞Ki-67增殖指数>95%,原位杂交检测肿瘤细胞EBER阳性。结论:精囊原发性BL是一种非常罕见的高度恶性的肿瘤,病程进展快,诊断时应除外精囊外BL累及,确诊依赖病理组织学和实验室检查,并需要与精囊或前列腺发生的弥漫性大B细胞性淋巴瘤、淋巴母细胞淋巴瘤和小细胞癌鉴别。
Objective: To report the clinicopathological features of primary Burkitt’s lymphoma (BL). Methods: The clinical features, histology, immunohistochemistry and in situ hybridization of 1 case of primary BL were observed. The pathological features and differential diagnosis of 1 case were analyzed. Results: The clinical manifestations of this case were characterized by frequent micturition and dysuria. Enlarged inguinal lymph nodes occurred 2 months after onset. Imaging showed that the lesion showed low density seminal vesicle shadow, histology showed diffuse monomolecular size of infiltrative tumor cells with neoplastic necrosis, mitotic easy to see and “sky ” image. Immuno-labeled tumor cells expressed CD10, CD20, CD79α and Bcl-6, but lacked CD3, CD5, CD23, MPO, Bcl-2, CyclinD1 and TdT expression. Ki-67 proliferation index of tumor cells was> 95% EBER positive cells. Conclusion: The seminal vesicle primary BL is a very rare and highly malignant tumor with rapid progression. Excluding extra-seminal vesicle BL should be excluded in the diagnosis. The diagnosis depends on histopathology and laboratory tests and needs to be diffused with seminal vesicle or prostate Large B-cell lymphoma, lymphoblastic lymphoma and small cell carcinoma.