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目的甲状腺原发性Burkitt淋巴瘤非常罕见,对其临床病理特点进行探讨。方法对1例患有甲状腺Burkitt淋巴瘤的9岁男童进行详细的临床资料和病理形态学观察,并采用MaxVision法进行免疫组化染色、EBER原位杂交和c-myc基因FISH检测。结果甲状腺组织内见中等大小异型淋巴细胞弥漫浸润,可见明显“星空”现象。肿瘤细胞CD20、CD10、bcl-6、CD43和CD38(+),CD3、CD5、bcl-2和TDT均(-),Ki-67阳性率>95%。FISH检测有c-myc基因位点的染色体断裂重组。EBER分子原位杂交(-)。结论本例为原发于甲状腺的散发型Burkitt淋巴瘤,与EBV感染无关。需要与弥漫性大B细胞性淋巴瘤、结外黏膜相关淋巴组织边缘区淋巴瘤和B淋巴母细胞性淋巴瘤/白血病进行鉴别。
Objective Thyroid primary Burkitt lymphoma is very rare, its clinical and pathological features are discussed. Methods A 9-year-old boy with thyroid Burkitt’s lymphoma was studied by detailed clinical data and histopathology. MaxVision immunohistochemical staining, EBER in situ hybridization and c-myc FISH were performed. Results Thyroid tissue see medium-sized allogeneic lymphocytes diffuse infiltration, visible “star” phenomenon. The positive rate of Ki-67 was> 95% in tumor cells including CD20, CD10, bcl-6, CD43 and CD38 (+), CD3, CD5, bcl-2 and TDT. FISH detected c-myc gene locus chromosome rupture recombination. EBER molecular in situ hybridization (-). Conclusion This example is a hairy Burkitt’s lymphoma that originates in the thyroid gland and has nothing to do with EBV infection. Need to be distinguished from diffuse large B-cell lymphoma, extranodal mucosa-associated lymphoid marginal zone lymphoma and B-lymphoblastic lymphoma / leukemia.