颅面畸形是由多病因造成的胚胎发育不良而导致的颅面结构紊乱,是一类较常见的人类先天性疾病,约占所有人类先天性疾病中的1/3。以前人们对遗传和发育在颅面畸形形成中的作用所知有限,最近分子遗传学和发育生物学研究有了重要进展,认识到颅面畸形与遗传缺陷及胚胎发育过程中颅间充质细胞的协调分化和精细选择有关。 Craniofacial deformity is a disorder of craniofacial structure caused by multiple causes of embryonic hypoplasia. It is a common type of congenital human disease and accounts for about one-third of all human congenital diseases. In the past, there was little known about the role of heredity and development in the formation of craniofacial deformity. Recent advances in molecular genetics and developmental biology have made great progress. He realized that craniofacial deformities and genetic defects, as well as intracranial mesenchymal cells The coordination of differentiation and fine selection.