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目的 :应用庆大霉素缓释片 +法莫替丁 +阿莫西林组成三联疗法 ,与其他方案作比较 ,观察其根除 HP感染的疗效。方法 :HP阳性的胃病患者 187例 ,随机分成两组 :A组 :法莫替丁 2 0 mg/次 +阿莫西林 5 0 0 mg/次 +庆大霉素缓释片 80 mg/次 ,均 2次 /d,疗程 14 d。 B组 :法莫替丁 2 0 mg/次 +阿莫西林 5 0 0 mg/次 +甲硝唑 40 0 mg/次 ,均 2次 /d,疗程 14 d。观察记录 HP根除情况。临床症状改善情况及不良反应。结果 :187例完成治疗及复查。 HP根除率 A、 B两组分别为 83 .4%、 86.3 %差异无显著性 ( P>0 .0 5 ) ,A组在治疗过程中毒副作用明显低于 B组 ( P<0 .0 5 )。结论 :含庆大霉素三联疗法根除 HP效果与法莫替丁 +阿莫西林 +甲硝唑相同 ,毒副作用却很低 ,是一个良好的初治方案
OBJECTIVE: To compare the efficacy of gentamicin sustained-release tablets plus famotidine plus amoxicillin in the treatment of HP infection by comparing with other regimens. Methods: A total of 187 HP-positive gastric patients were randomly divided into two groups: group A: famotidine 20 mg / time + amoxicillin 500 mg / time + gentamycin sustained-release tablets 80 mg / time, 2 times / d, treatment 14 d. Group B: famotidine 20 mg / time + amoxicillin 500 mg / time + metronidazole 40 0 mg / time, all 2 times / d, treatment 14 d. Observe and record HP eradication. Clinical symptoms and adverse reactions. Results: 187 cases completed the treatment and review. The eradication rate of group A and group B was 83.4% and 86.3%, respectively, and there was no significant difference (P> 0.05) between group A and group B. The toxic side effects in group A were significantly lower than those in group B (P <0.05) . Conclusion: The effect of gentamicin triple therapy on eradication of HP is the same as that of famotidine, amoxicillin and metronidazole, and the side effects are very low, which is a good initial regimen