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对47例流行性出血热（EHF）患者应用流行性出血热病毒（EHFV）抗原再次攻击后观察IgE，嗜酸粒细胞和临床变化以及EHFV抗原的皮试反应和皮窗试验中细菌渗出情况。结果发现EHFV抗原注射前后嗜酸粒细胞和血压等无明显变化；抗原注射前IgE正常的13例，注射后7例（53．83％）超出正常范围。皮试结果15min阳性14.8％，6h阳性57.44％，24～48h阳性8O.89％。皮窗试验淋巴细胞渗出较对照组明显升高，外单核细胞增高例数亦明显高于对照组。抗原组有3例嗜酸粒细胞增高。以上结果说明EHFV抗原再次攻击后可以出现Ⅰ、Ⅲ、Ⅳ型变态反应，但绝大多数为Ⅳ型变态反应。对以上各型变态反应在EHF发病中的作用进行探讨。
In 47 cases of epidemic hemorrhagic fever (EHF) patients with epidemic hemorrhagic fever virus (EHFV) antigen re-attack observed after IgE, eosinophils and clinical changes and EHFV antigen skin test reactions and skin window exudation in the case of bacteria . EHFV antigen injection before and after the results found no significant changes in eosinophils and blood pressure; IgE antigen injection before the normal in 13 cases, 7 cases (53.83%) after injection beyond the normal range. Skin test results 15min positive 14.8%, 6h positive 57.44%, 24 ~ 48h positive 8O.89%. Skin window test lymphocyte exudation than the control group was significantly increased, the number of cases of mononuclear cells was significantly higher than the control group. Antigen group, 3 cases of eosinophils increased. The above results suggest that EHFV antigen re-attack after the emergence of Ⅰ, Ⅲ, Ⅳ-type allergy, but the vast majority of type Ⅳ allergy. The above types of allergic reactions in the pathogenesis of EHF are discussed.