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目的:研究葛根素体外对高脂血症模型大鼠的降脂作用。方法:取60只SD大鼠,将其随机分为正常对照组、高脂模型组、阳性对照组(辛伐他汀片0.9 mg/kg)和葛根素组(高剂量20 mg/kg、中剂量10 mg/kg、低剂量5 mg/kg);采用高脂饲料喂养大鼠并给药30 d后,采集大鼠血液标本,测定血液流变学、血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)含量,以及测定肝脏中血清总胆固醇(TC)、三酰甘油(TG)含量。结果:葛根素(高、中剂量组)能显著降低模型大鼠的全血全切变率(1/s)和血浆黏度,以及降低血液中TC、TG、LDL的含量和肝脏中TC、TG的含量,显著升高HDL的含量,与模型组比较其差异有统计学意义(P<0.01)。结论:葛根素体外对高脂血症模型大鼠具有显著的降脂作用。
Objective: To study the lipid-lowering effect of puerarin on hyperlipidemia model rats. Methods: Sixty SD rats were randomly divided into normal control group, high fat model group, positive control group (simvastatin 0.9 mg / kg) and puerarin group (high dose 20 mg / kg, medium dose 10 mg / kg, and low dose 5 mg / kg). The rats were fed with high-fat diet for 30 days and blood samples of rats were collected to measure the blood rheology, serum total cholesterol (TC), triglyceride TG, HDL and LDL, as well as the levels of serum total cholesterol (TC) and triglyceride (TG) in the liver. Results: Puerarin (high and middle dose groups) could significantly reduce the whole blood shear rate (1 / s) and the plasma viscosity of model rats, as well as reduce the levels of TC, TG and LDL in the blood and the levels of TC, TG (P <0.01). Compared with the model group, the difference was statistically significant (P <0.01). Conclusion: Puerarin in vitro hyperlipidemia model rats have significant lipid-lowering effect.