10名健康志愿受试者每晚10∶30分给予一次25ｍｇ或100ｍｇＯｒｇ4428,(一种高度特异性去甲肾上腺素再摄取抑制剂)与接受安慰药对照者比较睡眠脑电图描记(ＥＥＧ)急性变化。结果表明,Ｏｒｇ4428以抗抑郁药方式影响睡眠ＥＥＧ波谱;ＲＥＭ(快动眼)睡眠受到抑制,且ＲＥＭ潜伏期延长 Ten healthy volunteers were given either 25 mg or 100 mg of Org4428 at 10:30 p.m., a type of highly specific norepinephrine reuptake inhibitor, compared with those receiving placebo-controlled sleep encephalography (EEG) Variety. The results showed that Org4428 could affect the sleep EEG spectrum with antidepressant drugs; REM (rapid eye movement) sleep was inhibited and REM latency was prolonged