23例肝硬化病人的血清肌酐和血尿素氮浓度均属正常。其中17例并发中、重度腹水,余下6例患门脉高压性食管静脉曲张。患动脉高血压、呼吸系统或心脏疾病、糖尿病或肝细胞癌的病人不在研究范围内。研究前2个月内所有病人均无细菌感染、胃肠出血和肝性脑病。病人连续6天饮服50mEq 的钠后进入研究,但不服用利尿荆或其它药物。第7天开始取血样和24小时尿量,分别进行标准肝、肾功能试验及电解质排泄测定。第8天早上经整夜空腹和2小时卧床休息后,在对照期和研究期各90分钟内分别不注射或连续静注生长抑素(so-matostatin),并测定平均动脉压、肾血浆流量(RPF)、肾小球滤过率(GFR)、最大尿钠排泄量及游离水清除。在对照期给予水负荷,亦即按5%葡萄糖20ml/kg 体重作静脉滴注。以后在整个研究期间,按丢失尿量补回同量的5%葡萄 Serum creatinine and blood urea nitrogen levels in 23 patients with cirrhosis were normal. Among them, 17 cases were complicated with moderate to severe ascites and the remaining 6 cases had portal hypertension varices. Patients with arterial hypertension, respiratory or heart disease, diabetes, or hepatocellular carcinoma are beyond the study. All patients had no bacterial infection, gastrointestinal bleeding and hepatic encephalopathy in the first 2 months of the study. The patient entered the study after taking 50 mEq sodium for 6 consecutive days, but did not take diuretic or other drugs. On the seventh day, blood samples and 24-hour urine volume were taken, and standard liver and renal function tests and electrolyte excretion were performed respectively. On the 8th day after fasting overnight and rest in bed for 2 hours, somatostatin was not injected or continuously injected for 90 minutes during the control period and the study period respectively. Mean arterial pressure, renal plasma flow rate (RPF), glomerular filtration rate (GFR), maximum urinary sodium excretion and free water clearance. In the control period given water load, that is, by 5% glucose 20ml / kg body weight for intravenous drip. Later during the entire study, the same amount of 5% grapes were replenished at the loss of urine volume