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结直肠癌（CRC）是通过一系列明显的组织学阶段发展的，它从正常的粘膜发展为癌前腺瘤性息肉最后成癌。以前研究在分析给予了致癌物的啮齿动物的整个结肠标本认为具有显微镜下的腺体缺损叫结肠腺体缺损病灶（ACF）。ACF可能是在腺瘤生长以前的一个明显的组织学缺损，它是由成群
Colorectal cancer (CRC) develops through a series of distinct histological stages that progress from normal mucosa to precancerous adenomatous polyps. Previous studies in the entire colon that analyzed rodent animals given carcinogens were considered to have a microscopic glandular defect called the colon gland-defective lesion (ACF). ACF may be an obvious histological defect before the growth of adenomas. It is caused by clusters.