论文部分内容阅读
急性髓性白血病(AML)在首次疾病发作后复发比例高.仅有20%～25%AML病人可保持终身缓解,而且复发后预后差,缓解期短,极少有长期存活者.AML病人的外周血原始细胞可在体外被白细胞介素-2(IL-2)激活的异源性自然杀伤(NK)细胞有效溶解.通过外周血离心淘析取得的单核细胞对IL-2诱导的AML原始细胞杀伤具有抑制作用,而微克分子浓度的组织胺可消除单核细胞诱导的对NK细胞的抑制作用.所以,组织胺和IL-2可起协同作
Acute myeloid leukemia (AML) has a high rate of relapse after the onset of the first disease. Only 20% to 25% of AML patients can maintain life-long remission, and the prognosis is poor after relapse. The remission period is short and there are few long-term survivors. Peripheral blood progenitor cells can be efficiently solubilized by exogenous natural killer (NK) cells activated by interleukin-2 (IL-2) in vitro. Mononuclear cells obtained by centrifugation of peripheral blood to IL-2 induced AML Protocell killing has an inhibitory effect, while histamine at a micromolar concentration eliminates monocyte-induced inhibition of NK cells. Therefore, histamine and IL-2 may act synergistically.