骨髓增生异常综合征(MDS)转变为急性白血病者屡见报道,而转变为骨髓纤维化(MF)实属罕见。现将我院经骨髓活检证实的二例报告如下. 临床资料例1,女,38岁,工人。因头晕乏力、面色苍白及齿龈时有出血2个月,于1987年6月4日以贫血原因待查入院.查体:体温37.8℃,中度贫血貌,全身皮肤粘膜无出血点及瘀斑,浅表淋巴结不肿大,肝大肋下2指,脾未扪及。实验室检查:血红蛋白58g/L,网织红细胞计数0.04,血小板数70×10~9/L,白细胞数8.7×10~9/L,中性粒细胞0.73,淋巴细胞0.25,中、晚幼粒细胞各占0.01,晚幼红细胞0.01,中性粒细胞见Pelser样核异常0.10。骨髓增生为极度活跃,粒系 Myelodysplastic syndromes (MDS) into acute leukemia are frequently reported, and to change to myelofibrosis (MF) is rare. Now my hospital bone marrow biopsy confirmed the two cases are as follows.Clinical data example 1, female, 38 years old, workers. Bleeding due to dizziness, pale and gum bleeding for 2 months, on June 4, 1987 to be admitted to the hospital due to anemia. Physical examination: body temperature 37.8 ℃, moderate anemia appearance, systemic skin and mucous membrane without bleeding spots and ecchymosis , Superficial lymph nodes are not swollen, liver ribs 2 means, the spleen is not palpable. Laboratory tests: hemoglobin 58g / L, reticulocyte count 0.04, the number of platelets 70 × 10 ~ 9 / L, the number of white blood cells 8.7 × 10 ~ 9 / L, neutrophils 0.73, lymphocytes 0.25, 0.01 for each cell, 0.01 for neutrophil, and 0.10 for Pelser-like neutrophil. Myeloid hyperplasia is extremely active, myeloid lineage