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目的 :观察静脉用地尔硫卓对难治性不稳定型心绞痛 (UAP)患者的短期疗效、安全性及不良反应。方法 :选择 32例难治性UAP患者 ,静脉注射地尔硫卓 10mg后 ,继以 3~ 15mg静脉点滴维持 4 8h(对入选时心绞痛未发作者直接给予持续静脉滴注 ) ,观察心绞痛症状、心电图及血压、心率变化。结果 :32例UAP患者开始用药后 4 8h内与用药前 4 8h比较 ,平均心绞痛发作次数减少 ,平均心绞痛最长持续时间缩短 ,其中 16例患者在用药开始后 4 8h内未再发作心绞痛 ;治疗后 2 4h和 4 8h心电图缺血性表现明显改善 ;血压下降 ,心率减慢 ,心肌耗氧量指标降低 ;出现 1例窦性心动过缓、1例低血压、1例头痛和 1例胃肠道反应 ,经处理后均恢复。结论 :短期静脉用地尔硫卓是一项缓解难治性UAP患者症状、改善心肌缺血的安全而有效措施。
Objective: To observe the short-term efficacy, safety and adverse reactions of intravenous diltiazem in patients with refractory unstable angina pectoris (UAP). Methods: Thirty-two patients with refractory UAP were selected and treated with intravenous diltiazem 10mg. The patients were treated with intravenous infusion of 3-15mg intravenously for 48 hours (continuous intravenous infusion was given directly to those who did not have angina at the time of selection), angina pectoris, electrocardiogram and blood pressure , Heart rate changes. Results: The average duration of angina pectoris and the longest duration of mean angina pectoris were shortened in 48 UAP patients within 48 h after the start of medication, and no recurrence of angina was found in 16 patients within 48 h after the start of medication The electrocardiographic ischemic performance was significantly improved after 24 h and 48 h. The blood pressure decreased, the heart rate slowed down, and the myocardial oxygen consumption decreased. One case of sinus bradycardia, one case of hypotension, one case of headache and one case of gastrointestinal Road reaction, after treatment were restored. Conclusion: Diltiazem for short-term intravenous use is a safe and effective measure to relieve symptoms and improve myocardial ischemia in patients with refractory UAP.