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目的探讨岩舒注射液联合放疗治疗中晚期食管癌的近期疗效、毒副反应及生活质量。方法将符合入组条件的46例中晚期食管癌患者随机分为2组,2组放疗方案相同,治疗组在放疗同时给予岩舒注射液20 mL加生理盐水250 mL静脉滴注,每日1次,放疗第1天开始到最后1次结束。观察患者近期疗效、毒副反应及生活质量。结果治疗组和对照组的有效率分别为78%和56%,2组比较有显著性差异(P<0.05)。治疗组毒副反应发生率低于对照组,生活质量改善情况明显优于对照组。结论放疗合并岩舒注射液治疗中晚期食管癌可提高临床疗效,改善生活质量,降低放疗毒副反应,有一定临床意义。
Objective To explore the short-term curative effect, side effects and quality of life of Yan Shu injection combined with radiotherapy in the treatment of advanced esophageal cancer. Methods Forty-six patients with advanced esophageal cancer who met the inclusion criteria were randomly divided into two groups. The two groups received the same radiation regimen. The patients in the treatment group received Yan Shu injection 20 mL plus normal saline 250 mL intravenously once a day Times, the first day of radiotherapy to the end of the last one. To observe the recent efficacy of patients, toxic side effects and quality of life. Results The effective rates of the treatment group and the control group were 78% and 56%, respectively. There were significant differences between the two groups (P <0.05). The incidence of adverse reactions in the treatment group was lower than that in the control group, and the quality of life improvement was better than that in the control group. Conclusion Radiotherapy combined with Yanshu injection in the treatment of advanced esophageal cancer can improve the clinical curative effect, improve the quality of life and reduce the side effects of radiotherapy, which has some clinical significance.