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目的:研究健康人单剂量口服氢溴酸西酞普兰片的药动学。方法:选择中国健康男性志愿者12名,单次口服氢溴酸西酞普兰片40mg,用HPLC法测定血药浓度,用3P97软件拟合药动学参数。结果:受试者口服氢溴酸西酞普兰片,体内过程呈二房室模型,主要药动学参数:Cmax为(45.6±9.5)μg.L-1,tmax为(3.4±2.2)h,AUC0-∞为(2 008.4±475.8)μg.h.L-1,t1/2β为(40.2±7.8)h。结论:单次口服氢溴酸西酞普兰片40mg可在人体内达到有效血浆浓度,可推荐临床应用。
Objective: To study pharmacokinetics of single oral citalopram hydrobromide tablets in healthy volunteers. Methods: Twelve healthy male volunteers in China were enrolled in this study. 40mg of citalopram hydrobromide was given orally. The plasma concentration was determined by HPLC. The pharmacokinetic parameters were fitted by 3P97 software. RESULTS: Citalopram hydrobromide was administered orally in a two-compartment model. The main pharmacokinetic parameters were Cmax (45.6 ± 9.5) μg.L-1, tmax (3.4 ± 2.2) h, AUC0 -∞ was (2 008.4 ± 475.8) μg.hL-1, and t1 / 2β was (40.2 ± 7.8) h. Conclusion: A single oral citalopram hydrobromide tablets 40mg in the human body to achieve effective plasma concentrations, can be recommended for clinical use.