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目的研究飞机草对小鼠急性软组织损伤的治疗作用及其可能机制。方法将动物随机分成空白对照组、模型对照组、阳性对照组、飞机草高、低剂量组,除空白对照组外,其余各组小鼠用重物砸伤造成软组织损伤模型,应用比色法,ELISA法动态测定损伤组织中SOD活性和MDA、PGE2、NO的水平。另于给药后第8天取各组余下10只小鼠损伤肌肉,固定于福尔马林,做病理学观察。结果飞机草高剂量在试验期间能明显升高重物砸伤后损伤组织SOD活性(P<0.05),明显降低损伤组织MDA、NO、PGE2水平(P<0.05),而低剂量仅在给药后第5天明显升高重物砸伤后损伤组织SOD活性(P<0.05);明显降低重物砸伤后损伤组织MDA、NO、PGE2水平(P<0.05)。受损骨骼肌HE染色结果显示飞机草给药后第8天,受损组织炎性反应消失,大量成纤维细胞增殖,断端纤维连接。结论飞机草可通过提高SOD活性,降低MDA、NO、PGE2水平来发挥对急性软组织损伤的治疗作用。
Aim To study the therapeutic effect and its possible mechanism of Aloe vera on acute soft tissue injury in mice. Methods The animals were randomly divided into blank control group, model control group, positive control group, airplane grass high and low dose groups, except the blank control group, the other groups of mice were injured by heavy objects to cause soft tissue injury model, The activity of SOD and the content of MDA, PGE2 and NO in injured tissue were measured by ELISA. The other day after administration, the remaining 10 mice in each group were sacrificed and fixed in formalin for pathological observation. Results The high dose of Pseudostellaria plantarum significantly increased the activity of SOD (P <0.05), and significantly decreased the level of MDA, NO and PGE2 (P <0.05) On the fifth day after the injury, the SOD activity in injured tissues was significantly increased (P <0.05), and the levels of MDA, NO and PGE2 in injured tissues were significantly decreased (P <0.05). HE staining of damaged skeletal muscle showed that on the 8th day after the administration of the airplane grass, the inflammatory reaction of the damaged tissue disappeared, a large number of fibroblasts proliferated and the stump fibers were connected. Conclusion Air grass can play a therapeutic role in acute soft tissue injury by increasing SOD activity and decreasing MDA, NO and PGE2 levels.