p73是最近发现的p53家族的一员,它与p53不仅在蛋白结构上具有较高的同源性,功能也具有一定的相似性,被认为是一种潜在的抑癌基因。但随着研究的深入,发现P73在功能和调控机制上与P53都具有不同点。P73具有诱导细胞凋亡的能力,其机制与P53不同。P73在很多肿瘤中的表达高于相应的正常组织,这与经典的抑癌基因也不同。因此对于P73基因仍需进一步的研究。 P73 is a member of the recently discovered p53 family. It is not only a protein with high homology but also a certain similarity in function. It is considered as a potential tumor suppressor gene. However, with further research, we found that P73 has different functions and regulatory mechanisms from P53. P73 has the ability to induce apoptosis, and its mechanism is different from P53. P73 expression in many tumors is higher than the corresponding normal tissue, which is different from the classical tumor suppressor genes. So for the P73 gene still needs further study.