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应用抗人T淋巴细胞单克隆抗体CD系列检测30例慢性丙型肝炎病例以及20例健康成人的外周血T淋巴细胞CD_3、CD_4、CD_8、CD_16亚群,以APAAP免疫酶标染色法测定。结果发现:慢性丙型肝炎组CD_4细胞数较正常对照组明显降低,CD_8细胞数较正常对照组明显升高,CD_3、CD_16细胞数与正常对照组无显著差异。认为T淋巴细胞亚群异常所致的细胞免疫紊乱可能是慢性丙型肝炎发病的重要原因。
Serum CD_3, CD_4, CD_8 and CD_16 subsets of peripheral blood T lymphocytes in 30 chronic hepatitis C cases and 20 healthy adults were detected by anti-human T-lymphocyte monoclonal antibody CD series and detected by APAAP immunostaining. The results showed that the number of CD_4 cells in chronic hepatitis C group was significantly lower than that in normal control group, the number of CD_8 cells was significantly higher than that in normal control group, and the number of CD_3 and CD_16 cells was not significantly different from that in normal control group. It is thought that the disorder of cellular immunity caused by abnormal T lymphocyte subsets may be the important reason of chronic hepatitis C.