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目的:研究血清肌酐(serum creatinine,SCr)与非ST段抬高急性冠脉综合征(non-ST-elevation acute coronary syndrome,NSTE-ACS)患者冠脉病变程度及其预后的关系。方法:对293例患者进行回顾性分析,依据冠脉造影结果分为NSTE-ACS组和非冠心病组。根据Gensini积分系统,评价NSTE-ACS患者冠脉病变程度,并将患者分为轻度病变组、中度病变组和重度病变组。检测患者SCr水平,应用SPSS16.0分析SCr与NSTE-ACS患者冠脉病变程度及其预后关系。结果:(1)与非冠心病组相比,NSTE-ACS患者SCr较高(P<0.05);其中,重度冠脉病变NSTE-ACS患者SCr水平尤高(P<0.001)。(2)SCr是NSTE-ACS冠脉病变的危险因子;SCr与NSTE-ACS冠脉病变程度呈正相关(r=0.263,P<0.000);SCr与NSTE-ACS主要心血管不良事件(Major Adverse Cardiovascular Events,MACE)呈正相关(r=0.183,P<0.01)。结论:SCr是NSTE-ACS患者冠脉病变的独立危险因子,且与NSTE-ACS患者预后相关。SCr对于NSTE-ACS的诊疗有潜在临床价值。
Objective: To investigate the relationship between serum creatinine (SCr) and coronary artery disease and its prognosis in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods: 293 patients were retrospectively analyzed. According to the results of coronary angiography, they were divided into NSTE-ACS group and non-coronary heart disease group. According to the Gensini score system, the degree of coronary artery lesion in patients with NSTE-ACS was evaluated, and the patients were divided into mild lesion group, moderate lesion group and severe lesion group. The level of SCr in patients was detected. The relationship between the severity of coronary lesions and prognosis of patients with SCr and NSTE-ACS was analyzed by SPSS16.0. Results: (1) Compared with non-coronary heart disease group, SCr was higher in patients with NSTE-ACS (P <0.05). Among them, SCr level in patients with severe coronary artery disease was particularly high (P <0.001). (2) SCr was a risk factor of coronary artery disease in NSTE-ACS group; SCr was positively correlated with the severity of coronary artery disease in NSTE-ACS group (r = 0.263, P <0.000); SCr and NSTE-ACS major adverse cardiac events Events, MACE) (r = 0.183, P <0.01). Conclusion: SCr is an independent risk factor for coronary artery disease in patients with NSTE-ACS and is related to the prognosis of patients with NSTE-ACS. SCr has potential clinical value for the treatment of NSTE-ACS.