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转化生长因子β(TGFβ)是一种多功能的细胞因子 ,通过相应受体的介导 ,对肿瘤细胞的生长具有抑制作用。细胞失去对TGFβ生长抑制作用的敏感性可能是膀胱癌变过程中的一个重要步骤。本文就TGFβ及其受体与膀胱癌的关系做一综述
Transforming growth factor β (TGFβ) is a multifunctional cytokine which inhibits the growth of tumor cells through the mediation of the corresponding receptors. Sensitivity of cells to loss of inhibitory effect on TGFβ growth may be an important step in bladder carcinogenesis. This article reviews the relationship between TGFβ and its receptor and bladder cancer