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目的 :评价羟基喜树碱 (HCPT)、顺铂 (DDP)和长春新碱 (VCR)治疗晚期非小细胞肺癌 (NSCL C)的疗效和毒副作用。方法 : b～ 期肺癌 34例 ,初治 2 3例 ,复治 11例。HCPT10 m g/ d,连用 5天～ 10天 ,DDP80mg/ m2 ,分 3天应用 ,VCR 2 mg,d1 ,4周为 1疗程。结果 :32例可评价疗效 ,总有效率 43.8% (14/ 32 ) ,CR 1例 ,PR13例。毒副作用主要为骨髓抑制、消化道反应和脱发。结论 :该方案治疗 NSCL C有较好的疗效 ,毒副作用不大 ,但应注意白细胞下降的预防
Objective: To evaluate the efficacy and toxic side effects of HCPT, cisplatin (DDP) and vincristine (VCR) in the treatment of advanced non-small cell lung cancer (NSCL C). Methods: 34 cases of b-stage lung cancer, 23 cases of initial treatment, and 11 cases of retreatment. HCPT 10 mg/day, continuous use for 5 days to 10 days, DDP 80 mg/m2, application for 3 days, VCR 2 mg, d1, 4 weeks for 1 course of treatment. Results: 32 cases could evaluate the curative effect, the total effective rate was 43.8% (14/32), CR was 1 case, PR 13 cases. The toxic side effects are mainly myelosuppression, gastrointestinal reactions and hair loss. Conclusion: This regimen has good curative effect on NSCL C with few side effects, but attention should be paid to the prevention of leukocyte decline.