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由于环孢菌素(CS)对T淋巴细胞的独特作用,现已被应用到微小病变型(MCNS)和局灶硬化型(FSGS)肾病的治疗。本文作者报告了14例特发性肾病综合征儿童应用CS治疗后的初步结果。一、微小病变型肾病综合征 7例激素依赖型肾病综合征儿童(男6例,女1例),曾用细胞毒药物治疗无效,在用激素使病情缓解后开始应用CS,开始剂量为100mg/m~2/日分二次口服,逐渐加量至血中浓度谷值达到200～400ng/ml,开始4—8周合用强的松隔日服,6个月为一个疗程,比较应用CS前,中,后各6个月的复发情况。
Due to its unique effect on T lymphocytes, cyclosporin (CS) has now been used in the treatment of minimally pathological (MCNS) and focal sclerosis (FSGS) nephropathy. The authors report preliminary results of 14 children with idiopathic nephrotic syndrome treated with CS. First, minimal change nephrotic syndrome 7 cases of hormone-dependent nephrotic syndrome in children (6 males and 1 females), had been treated with cytotoxic drugs ineffective, with hormones to ease the condition began to use CS, the initial dose of 100mg / m ~ 2 / day sub-second oral, gradually increase the blood concentration to the valley reached 200 ~ 400ng / ml, beginning 4-8 weeks with prednisone every other day, 6 months for a course of treatment, compared with CS , In the after 6 months of recurrence.