论文部分内容阅读
对３６３例２型糖尿病先证者家系及２９１例人群对照家系进行了以人群为基础的遗传流行病学病例－对照研究。结果显著的：糖尿病先证者一级亲属（父母、同胞、子女）的累积发病率为３．９４％，对照组一级亲属１．０９％，相对危险度（ＲＲ）为３．６２，差异有非常显著性意义（χ２＝３６．５４，Ｐ＜０．００１）；无论男性或女性一级亲属，先证者组的累积发病率均非常显著地高于人群对照组；诊断时年龄＜５５岁先证者的一级亲属，其糖尿病累积发病率和相对危险度均显著高于诊断年龄＞５５岁组。二项分布显示先证者一级亲属中２型糖尿病的分布呈明显的家庭聚集性，先证者一级亲属的遗传度为４０．４％（男性４２．６％，女性３８．６％）；２型糖尿病在同胞中的分离比为０．０３２，显著低于０．２５，不符合单基因遗传的特征。
A population-based case-control study of genetic epidemiology was performed in 363 family members with type 2 diabetes probands and 291 family controls. The results were significant: the cumulative incidence of first-degree relatives (parents, siblings, children) of probands in diabetes was 3.94%, while that of first-degree relatives in control group was 1.09%, the relative risk (RR) was 3.62 (Χ2 = 36.54, P <0.001). The cumulative incidence of probands in both male and female first-degree relatives was significantly higher than that in the control subjects. The age at diagnosis was lower than 55 First-degree relatives of first-degree relatives, the cumulative incidence of diabetes and relative risk were significantly higher than the age of diagnosis> 55 years old group. The binomial distribution showed that the distribution of type 2 diabetes in first-degree relatives of probands showed a significant family aggregation. The heritability of first-degree relatives of probands was 40.4% (42.6% for males and 38.6% for females) ; Type 2 diabetes in siblings segregation ratio was 0.032, significantly lower than 0.25, does not meet the characteristics of single-gene inheritance.